| 1 |
24336569 |
2014 |
Science |
Genetic Screens in Human Cells Using the CRISPR-Cas9 System |
Lander ES |
| 2 |
24336571 |
2014 |
Science |
Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells |
Zhang F |
| 3 |
24535568 |
2014 |
NatBiotechnol |
Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library |
Yusa K |
| 4 |
25494202 |
2015 |
Nature |
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex |
Zhang F |
| 5 |
25748654 |
2015 |
Cell |
Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis |
Sharp PA |
| 6 |
26232224 |
2015 |
Cell |
An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis |
Sabatini DM |
| 7 |
26472758 |
2015 |
Science |
Identification and characterization of essential genes in the human genome |
Sabatini DM |
| 8 |
26627737 |
2015 |
Cell |
High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities |
Moffat J |
| 9 |
26673326 |
2015 |
CellRep |
Genome-wide CRISPR-Cas9 Screens Reveal Loss of Redundancy between PKMYT1 and WEE1 in Glioblastoma Stem-like Cells |
Paddison PJ |
| 10 |
27260156 |
2016 |
CancerDiscov |
Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting |
Hahn WC |
| 11 |
27661255 |
2016 |
Elife |
Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation |
Weissman JS |
| 12 |
27760321 |
2016 |
CellRep |
A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia |
Yusa K |
| 13 |
27842070 |
2016 |
NatChemBiol |
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition |
Conrad M |
| 14 |
27869803 |
2017 |
NatMed |
Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors |
Angers S |
| 15 |
28162770 |
2017 |
Cell |
Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ra |
Sabatini DM |
| 16 |
28753430 |
2017 |
Cell |
Defining a Cancer Dependency Map |
Hahn WC |
| 17 |
28753431 |
2017 |
Cell |
Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screenin |
Sellers WR |
| 18 |
28813417 |
2017 |
Nature |
CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity |
Dawson MA |
| 19 |
30449619 |
2018 |
Cell |
Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function. |
Marson A |
| 20 |
30093494 |
2018 |
J Cell Bio. |
Genome-wide CRISPR screen identifies TMEM41B as a gene required for autophagosome formation |
Mizushima N |
| 21 |
29083409 |
2017 |
NatGenet |
Computational Correction of Copy Number Effect Improves Specificity of CRISPR-Cas9 Essentiality Screens in Cancer Cells |
Aviad Tsherniak |
| 22 |
31076567 |
2019 |
Oncogenesis |
A functional CRISPR/Cas9 screen identifies kinases that modulate FGFR inhibitor response in gastric cancer. |
Ji HP |
| 23 |
28611215 |
2017 |
PNAS |
Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. |
BrownM |
| 24 |
30865899 |
2019 |
Cell Rep |
Single-Cell Heterogeneity Analysis and CRISPR Screen Identify Key Beta-Cell-Specific Disease Genes. |
Li Y |
| 25 |
30971826 |
2019 |
Nature |
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens |
Garnett MJ |
| 26 |
31104942 |
2019 |
CellStemCell |
Intracellular Ca2+ Homeostasis and Nuclear Export Mediate Exit from Naive Pluripotency |
Merrill BJ |
| 27 |
31727847 |
2019 |
PNAS |
Deciphering essential cistromes using genome-wide CRISPR screens. |
Brown M |
| 28 |
31110351 |
2019 |
NatGenet |
Genome-scale screens identify JNK-JUN signaling as a barrier for pluripotency exit and endoderm differentiatio |
Huangfu D |
| 29 |
29987050 |
2018 |
PNAS |
Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. |
Brown M |
| 30 |
30951565 |
2019 |
PLosPathog |
Unique features in the intracellular transport of typhoid toxin revealed by a genome-wide screen |
Galan JE |
| 31 |
31022357 |
2019 |
FASEBJ |
Genome-wide CRISPR knockout screens identify NCAPG as an essential oncogene for hepatocellular carcinoma tumor growth |
Man Hui K |
| 32 |
31142663 |
2019 |
JVirol |
A CRISPR Activation Screen Identifies Genes That Protect against Zika Virus Infectio |
Sklan EH |
| 33 |
30323222 |
2018 |
Nat Commun |
CRISPR knockout screening identifies combinatorial drug targets in pancreatic cancer and models cellular drug response. |
Adli M |
| 34 |
31040274 |
2019 |
NatCommun |
Molecular Dissection of Box Jellyfish Venom Cytotoxicity Highlights an Effective Venom Antidot |
Neely GG |
| 35 |
30933966 |
2019 |
PLosBiol |
CRISPR Screening Using an Expanded Toolkit of Autophagy Reporters Identifies TMEM41B as a Novel Autophagy Facto |
Denic V |
| 36 |
30773341 |
2019 |
Cancer Cell |
ARv7 Represses Tumor-Suppressor Genes in Castration-Resistant Prostate Cancer. |
Brown M |
| 37 |
29438694 |
2018 |
Cancer Cell |
Allele-Specific Chromatin Recruitment and Therapeutic Vulnerabilities of ESR1 Activating Mutations |
Brown M |
| 38 |
31113993 |
2019 |
Sci Rep |
Genome-scale CRISPR Cas9 screen determines factors modulating sensitivity to ProTide NUC-1031 |
Reynolds PA |
| 39 |
31147448 |
2019 |
JExpMed |
Lysolipid Receptor Cross-Talk Regulates Lymphatic Endothelial Junctions in Lymph Nodes |
Hla T |
| 40 |
31167905 |
2019 |
JVirol |
TAF Family Proteins and MEF2C Are Essential for Epstein-Barr Virus Super-Enhancer Activity |
ZhaoB |
| 41 |
31289186 |
2019 |
mBio |
The Extracellular Domain of the beta2 Integrin beta Subunit CD18 Is Sufficient for Escherichia coli Hemolysin and Aggregatibacter actinomycetemcomitans Leukotoxin Cytotoxic Activity |
Welch RA |
| 42 |
31294695 |
2019 |
Elife |
The CUL5 ubiquitin ligase complex mediates resistance to CDK9 and MCL1 inhibitors in lung cancer cells |
Corn JE |
| 43 |
31300418 |
2019 |
Blood Adv |
Genome wide CRISPR screens reveal genetic mediators of cereblon modulator toxicity in primary effusion lymphoma |
Gottwein E |
| 44 |
31316073 |
2019 |
Nat Commun |
Pooled library screening with multiplexed Cpf1 library |
Draetta G |
| 45 |
31048320 |
2019 |
CancerDiscov |
The TP53 Apoptotic Network Is a Primary Mediator of Resistance to BCL2 Inhibition in AML Cell |
Tyner JW |
| 46 |
31073033 |
2019 |
JBioChem |
Genome-wide CRISPR-based gene knockout screens reveal cellular factors and pathways essential for nasopharyngeal carcinom |
Zhao B |
| 47 |
31527793 |
2019 |
NatMicrobiol |
Enterovirus pathogenesis requires the host methyltransferase SETD |
Carette JE |
| 48 |
31648989 |
2019 |
EBioMedicine |
MYC predetermines the sensitivity of gastrointestinal cancer to antifolate drugs through regulating TYMS transcriptio |
Lang JY |
| 49 |
26189680 |
2015 |
Cell |
A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks |
Aviv Regev |
| 50 |
28783722 |
2017 |
Nature |
Identification of essential genes for cancer immunotherapy |
Nicholas P. Restifo |
| 51 |
31657721 |
2019 |
Elife |
Cholesterol accessibility at the ciliary membrane controls hedgehog signalin |
Rohatgi R |
| 52 |
27383987 |
2016 |
Nature |
Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screen |
Carette JE |
| 53 |
27383988 |
2016 |
Nature |
A CRISPR screen defines a signal peptide processing pathway required by flaviviruses |
Diamond MS |
| 54 |
28494239 |
2017 |
Cell Host Microbe |
CRISPR/Cas9 Screens Reveal Epstein-Barr Virus-Transformed B Cell Host Dependency Factor |
Gewurz BE |
| 55 |
31422865 |
2019 |
Neuron |
CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons |
Kampmann M |
| 56 |
31436532 |
2019 |
ELife |
Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b- |
Senis YA |
| 57 |
31439014 |
2019 |
Genome Med |
Identifying Chemogenetic Interactions From CRISPR Screens With drug |
Hart T |
| 58 |
31503550 |
2019 |
JCI Insight |
Molecular Determinants of Response to High-Dose Androgen Therapy in Prostate Cancer |
Mostaghel EA |
| 59 |
31506018 |
2019 |
Open Biol |
A Consensus Set of Genetic Vulnerabilities to ATR Inhibitio |
Durocher D |
| 60 |
31508509 |
2019 |
Commun Biol |
Genome-scale CRISPR Knockout Screen Identifies TIGAR as a Modifier of PARP Inhibitor Sensitivity
|
Chien J |
| 61 |
28723893 |
2017 |
Nature |
In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target |
W. Nicholas Haining |
| 62 |
28813410 |
2017 |
Nature |
Identification of CMTM6 and CMTM4 as PD-L1 protein regulators |
Schumacher TNM |
| 63 |
29301958 |
2018 |
Science |
A major chromatin regulator determines resistance of tumor cells to T cell-mediated killing |
Kai W Wucherpfennig |
| 64 |
29776993 |
2018 |
Sci Immunol |
Tumor immune evasion arises through loss of TNF sensitivity |
Jane Oliaro |
| 65 |
30797773 |
2019 |
Cell Syst |
Convergent Identification and Interrogation of Tumor-Intrinsic Factors that Modulate Cancer Immunity In Vivo |
Sidi Chen |
| 66 |
31126740 |
2019 |
cancer cell |
SLC19A1 Is an Importer of the Immunotransmitter cGAMP |
Mark A. Dawson |
| 67 |
31365872 |
2019 |
cell reports |
CRISPR/Cas9 Screens Reveal Multiple Layers of B cell CD40 Regulation |
Benjamin E. Gewurz |
| 68 |
31442407 |
2019 |
cell |
Systematic Immunotherapy Target Discovery Using Genome-Scale In Vivo CRISPR Screens in CD8 T Cells |
Sidi Chen |
| 69 |
31452512 |
2019 |
eLife |
Systematic identification of cancer cell vulnerabilities to natural killer cell- mediated immune surveillance |
Jeffrey Settleman |
| 70 |
31509742 |
2019 |
cell reports |
Natural Killer Cells Suppress T Cell-Associated Tumor Immune Evasion |
Jane Oliaro |
| 71 |
30559422 |
2018 |
nature method |
Tumor-derived IFN triggers chronic pathway agonism and sensitivity to ADAR loss |
E. Robert McDonald III |
| 72 |
31303383 |
2019 |
Cell |
Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold |
Daniel S. Peeper |
| 73 |
31564637 |
2019 |
cancer cell |
An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer |
Mark A. Dawson |
| 74 |
30397336 |
2018 |
nature genetic |
Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens |
Michael C. Bassik |
| 75 |
30639098 |
2018 |
Cell |
Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation |
Sarah A. Teichmann |
| 76 |
30955891 |
2019 |
Cell |
Somatic Mutations Increase Hepatic Clonal Fitness and Regeneration in Chronic Liver Disease
|
Zhu H |
| 77 |
29290584 |
2018 |
Dev Cell |
CRISPR Screens Uncover Genes That Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgeho |
Rohatgi R |
| 78 |
29478914 |
2018 |
Cancer Cell |
Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCP |
Maeda T |
| 79 |
28894007 |
2017 |
Proc Natl Acad Sci U S A |
RABIF/MSS4 is a Rab-stabilizing holdase chaperone required for GLUT4 exocytosi |
Shen J |
| 80 |
29038160 |
2017 |
Mol Cell Biol |
A High-Resolution Genome-Wide CRISPR/Cas9 Viability Screen Reveals Structural Features and Contextual Diversity of the Human Cell-Essential Proteom |
Tyers M |
| 81 |
31353312 |
2019 |
Dev Cell |
AAGAB Controls AP2 Adaptor Assembly in Clathrin-Mediated Endocytosi |
Shen J |
| 82 |
31391273 |
2019 |
J Virol |
A CRISPR Screen Identifies the Cell Polarity Determinant Crumbs 3 as an Adeno-associated Virus Restriction Factor in Hepatocyte |
Asokan A |
| 83 |
31391551 |
2019 |
Oncogene |
PORCN inhibition synergizes with PI3K/mTOR inhibition in Wnt-addicted cancer |
Virshup DM |
| 84 |
28813663 |
2017 |
CellRep |
A CRISPR Activation Screen Identifies a Pan-avian Influenza Virus Inhibitory Host Facto |
Heaton NS |
| 85 |
29642015 |
2018 |
CellRep |
Genome-wide CRISPR/Cas9 Screen Identifies Host Factors Essential for Influenza Virus Replicatio |
Manicassamy B |
| 86 |
29769725 |
2018 |
Nature |
Mxra8 is a receptor for multiple arthritogenic alphaviruse |
Diamond MS |
| 87 |
30305350 |
2018 |
JVirol |
Identification of Antinorovirus Genes in Human Cells Using Genome-Wide CRISPR Activation Screening
|
Virgin HW |
| 88 |
30655525 |
2019 |
NatCommun |
A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola viru |
Spiropoulou CF |
| 89 |
31019072 |
2019 |
ProcNatlAcadSciUSA |
Genome-wide CRISPR screen for Zika virus resistance in human neural cell |
Jaenisch R |
| 90 |
32210344 |
2020 |
Sci Rep |
CRISPR-based gene knockout screens reveal deubiquitinases involved in HIV-1 latency in two Jurkat cell model |
Ho DD |
| 91 |
31331377 |
2019 |
JExpClinCancerRes |
Functional Genomics Identifies Predictive Markers and Clinically Actionable Resistance Mechanisms to CDK4/6 Inhibition in Bladder Cancer
|
Nawroth R |
| 92 |
29720387 |
2018 |
RNA |
MicroRNA-focused CRISPR-Cas9 Library Screen Reveals Fitness-Associated miRNAs |
Lin |
| 93 |
30327475 |
2018 |
Nat commun |
Tracing the transitions from pluripotency to germ cell fate with CRISPR screenin |
Surani |
| 94 |
31673055 |
2019 |
Sci Rep |
Genome-scale CRISPR screens are efficient in non-homologous end- joining deficient cells |
Loizou J |
| 95 |
29914970 |
2018 |
Genome Res |
Genome-scale identification of cellular pathways required for cell surface recognitio |
Wright |
| 96 |
29996108 |
2018 |
Cell Rep |
Genome-wide CRISPR-KO Screen Uncovers mTORC1-Mediated Gsk3 Regulation in Naive Pluripotency Maintenance and Dissolution
|
Yusa |
| 97 |
30224801 |
2018 |
Nat Microbiology |
A CRISPR Screen Identifies IFI6 as an ER-resident Interferon Effector That Blocks Flavivirus Replication |
Schoggins |
| 98 |
30520725 |
2018 |
eLife |
A virus-packageable CRISPR screen identifies host factors mediating interferon inhibition of HIV |
Emerman M |
| 99 |
30902969 |
2019 |
Nat Commun |
Bcor loss perturbs myeloid differentiation and promotes leukaemogenesi |
Kats L |
| 100 |
31792210 |
2019 |
Nat Commun |
Genome-wide CRISPR Screen Identifies ELP5 as a Determinant of Gemcitabine Sensitivity in Gallbladder Cance |
Wang J |
| 101 |
30639242 |
2019 |
Mol Cell |
The Functional Proximal Proteome of Oncogenic Ras Includes mTORC |
Khavari PA |
| 102 |
32499641 |
2020 |
Nature |
CRISPR screen in regulatory T cells reveals modulators of Foxp3 |
Fang D |
| 103 |
31827283 |
2019 |
Nature |
Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy
|
Chi H |
| 104 |
30275317 |
2018 |
Proc Natl Acad Sci USA |
Role of PDGF Receptor-_ During Human Cytomegalovirus Entry Into Fibroblast |
Shenk T |
| 105 |
30718897 |
2019 |
Sci Rep |
Identification of Novel Regulatory Genes in APAP Induced Hepatocyte Toxicity by a Genome-Wide CRISPR-Cas9 Scree |
Ye SQ |
| 106 |
29554922 |
2018 |
Retrovirology |
A CRISPR screen for factors regulating SAMHD1 degradation identifies IFITMs as potent inhibitors of lentiviral particle deliver |
Emerman M |
| 107 |
29662124 |
2018 |
Nat Commun |
STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection expressio |
Greenberg HB |
| 108 |
31188495 |
2020 |
Hepatology |
Depletion of TRRAP Induces p53-Independent Senescence in Liver Cancer by Down-Regulating Mitotic Gene |
Xue W |
| 109 |
31406271 |
2019 |
Sci Rep |
SMARCA2-deficiency confers sensitivity to targeted inhibition of SMARCA4 in esophageal squamous cell carcinoma cell line |
Wohrle S |
| 110 |
31548614 |
2020 |
Oncogene |
Genome-wide screening identifies novel genes implicated in cellular sensitivity to BRAFV600E expressio |
Li S |
| 111 |
30588337 |
2018 |
Cell Death Discov |
SEC24A identified as an essential mediator of thapsigargin-induced cell death in a genome-wide CRISPR Cas9 scree |
Supattapone S |
| 112 |
32054864 |
2020 |
Nat Commun |
Cross-talks of glycosylphosphatidylinositol biosynthesis with glycosphingolipid biosynthesis and ER-associated degradatio |
Kinoshita T |
| 113 |
32441252 |
2020 |
eLife |
Parallel CRISPR-Cas9 screens clarify impacts of p53 on screen performanc |
Jackson S |
| 114 |
31830245 |
2019 |
Blood |
Integrated drug profiling and CRISPR screening identify essential pathways for CAR T-cell cytotoxicity
|
Mustjoki S |
| 115 |
31740584 |
2019 |
J Biol Chem |
Inducible Exoc7/Exo70 Knockout Reveals a Critical Role of the Exocyst in Insulin-Regulated GLUT4 Exocytosis |
Shen J |
| 116 |
31780813 |
2020 |
Leukemia |
Pre-clinical activity of combined LSD1 and mTORC1 inhibition in MLL-translocated acute myeloid leukaemia |
Somervaille T |
| 117 |
32030357 |
2019 |
Wellcome Open Res |
Genome-wide CRISPR Screening Identifies New Regulators of Glycoprotein Secretio |
Moreau K |
| 118 |
30251625 |
2018 |
eLife |
The Cargo Receptor SURF4 Promotes the Efficient Cellular Secretion of PCSK9
|
Ginsburg |
| 119 |
30846702 |
2019 |
Nat Commun |
Imaging Inflammation Using an Activated Macrophage Probe With Slc18b1 as the Activation-Selective Gating Target
|
Chang |
| 120 |
31209294 |
2019 |
Nat Cell Biol |
Myc and Dnmt1 Impede the Pluripotent to Totipotent State Transition in Embryonic Stem Cells
|
Zhang |
| 121 |
31253784 |
2019 |
Nat commun |
Death Effector Domain-Containing Protein Induces Vulnerability to Cell Cycle Inhibition in Triple-Negative Breast Cancer
|
Zhang |
| 122 |
31692446 |
2019 |
eLife |
Negative regulation of autophagy by UBA6-BIRC6 mediated ubiquitination of LC3 |
Bonifacino |
| 123 |
31855178 |
2019 |
eLife |
TLE3 loss confers AR inhibitor resistance by facilitating GR-mediated human prostate cancer cell growt |
van der Heijden MS |
| 124 |
30890156 |
2019 |
BMCGenomics |
Development of Drug-Inducible CRISPR-Cas9 Systems for Large-Scale Functional Screenin |
Chung N |
| 125 |
31744829 |
2019 |
CancerDiscov |
In Vivo?Epigenetic CRISPR Screen Identifies?Asf1a?as an Immunotherapeutic Target in?Kras-Mutant Lung Adenocarcinom |
Wong KK |
| 126 |
32416067 |
2020 |
Mol Cell |
Synthetic Lethal and Resistance Interactions With BET Bromodomain Inhibitors in Triple-Negative Breast Cance |
Polyak V |
| 127 |
32514112 |
2020 |
Nat Methods |
Multilayered VBC score predicts sgRNAs that efficiently generate loss-of-function allele |
Elling U |
| 128 |
30477585 |
2018 |
Genome Biol |
Pooled Extracellular Receptor-Ligand Interaction Screening Using CRISPR Activation
|
Wright |
| 129 |
31730859 |
2019 |
Cell |
A Compendium of Genetic Modifiers of Mitochondrial Dysfunction Reveals Intra-organelle Bufferin |
Mootha V |
| 130 |
32005150 |
2020 |
BMC Genomics |
Identification of Functional Regulatory Elements in the Human Genome Using Pooled CRISPR Screen |
Younger S |
| 131 |
29924860 |
2018 |
PLoS One |
CRISPR/Cas-based Customization of Pooled CRISPR Libraries
|
Kim |
| 132 |
29973717 |
2018 |
Nature |
CRISPR Screens Identify Genomic Ribonucleotides as a Source of PARP-trapping Lesions
|
Durocher |
| 133 |
31919360 |
2020 |
Nat Commun |
Genome-wide CRISPR Screen Identifies Host Dependency Factors for Influenza A Virus Infection
|
Hacohen |
| 134 |
29677511 |
2018 |
Cell |
An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistanc |
Pandolfi PP |
| 135 |
30991026 |
2019 |
CancerCell |
Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemia |
Gutierrez A |
| 136 |
31882897 |
2019 |
SciRep |
Genome-scale CRISPR activation screen uncovers tumor-intrinsic modulators of CD3 bispecific antibody efficacy
|
Daly C |
| 137 |
31915280 |
2020 |
Jvirol |
A Genome-Wide CRISPR-Cas9 Screen Identifies the Dolichol-Phosphate Mannose Synthase Complex as a Host Dependency Factor for Dengue Virus Infectio |
Meertens L |
| 138 |
31991288 |
2020 |
DNARepair |
CRISPR/CAS9-based DNA Damage Response Screens Reveal Gene-Drug Interaction |
Chen J |
| 139 |
31804951 |
2020 |
Genome Res |
A Genome-Wide Long Noncoding RNA CRISPRi Screen Identifies PRANCR as a Novel Regulator of Epidermal Homeostasis
|
Sun B |
| 140 |
32213627 |
2020 |
Sci Transl Med |
Applying Genome-Wide CRISPR-Cas9 Screens for Therapeutic Discovery in Facioscapulohumeral Muscular Dystroph |
Kunkel L |
| 141 |
30955884 |
2019 |
Cell |
A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinom |
Reya T |
| 142 |
30645648 |
2019 |
PLoS Pathog |
Reiterative Enrichment and Authentication of CRISPRi Targets (REACT) identifies the proteasome as a key contributor to HIV-1 latency
|
Zhou Q |
| 143 |
31165872 |
2019 |
Nucleic Acids Res |
A CRISPR/Cas9 screen identifies the histone demethylase MINA53 as a novel HIV-1 latency-promoting gene (LPG |
Zhu J |
| 144 |
30022168 |
2019 |
Nature |
The Shieldin complex mediates 53BP1-dependent DNA repair
|
Durocher |
| 145 |
31784416 |
2020 |
Mol Ther |
GPR108 Is a Highly Conserved AAV Entry Facto |
Vandenberghe L |
| 146 |
30787439 |
2019 |
Nature |
MHC class II proteins mediate cross-species entry of bat influenza viruse |
Stertz S |
| 147 |
32156810 |
2020 |
mBio |
Barrier-to-Autointegration Factor 1 Protects against a Basal cGAS-STING Respons |
Diamond MS |
| 148 |
28474669 |
2017 |
Nat Commun |
Genome-scale Measurement of Off-Target Activity Using Cas9 Toxicity in High-Throughput Screen |
Bassik M |
| 149 |
30135075 |
2018 |
GenesDev |
Genetic modifiers of the BRD4-NUT dependency of NUT midline carcinoma uncovers a synergism between BETis and CDK4/6i |
Elledge SJ |
| 150 |
31844142 |
2019 |
Sci Rep |
A genome-scale CRISPR/Cas9 knockout screening reveals SH3D21 as a sensitizer for gemcitabin |
Aburatani H |
| 151 |
30773463 |
2019 |
Cell Metab |
Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivit |
Wood K |
| 152 |
31666400 |
2019 |
SciTranslMed |
Inhibition of Mitochondrial Translation Overcomes Venetoclax Resistance in AML Through Activation of the Integrated Stress Respons |
Chan S |
| 153 |
32042151 |
2020 |
Nat Struct Mol Biol |
Cell fitness screens reveal a conflict between LINE-1 retrotransposition and DNA replicatio |
Burns KH |
| 154 |
32160526 |
2020 |
Cell |
A Genome-wide ER-phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylatio |
Corn JE |
| 155 |
32029474 |
2020 |
J Biol Chem |
A genome-wide CRISPR/Cas9 screen reveals that the aryl hydrocarbon receptor stimulates sphingolipid level |
Proia RL |
| 156 |
31801078 |
2019 |
Cell Rep |
Suppression of Ribosomal Pausing by eIF5A Is Necessary to Maintain the Fidelity of Start Codon Selectio |
Mendell JT |
| 157 |
32028983 |
2020 |
Genome Biol |
Systematic functional identification of cancer multi-drug resistance gene |
Neely GG |
| 158 |
32699298 |
2020 |
SciRep |
A pooled genome-wide screening strategy to identify and rank influenza host restriction factors in cell-based vaccine production platform |
Kamen AA |
| 159 |
32542389 |
2020 |
NucleicAcidsRes |
Genome-wide CRISPR synthetic lethality screen identifies a role for the ADP-ribosyltransferase PARP14 in DNA replication dynamics controlled by AT |
Moldovan GL |
| 160 |
30388412 |
2018 |
MolCell |
Genome-wide CRISPR-Cas9 Interrogation of Splicing Networks Reveals a Mechanism for Recognition of Autism-Misregulated Neuronal Microexon |
Emerman M |
| 161 |
32640256 |
2020 |
Immunity |
A Genome-wide CRISPR Screen Reveals a Role for the Non-canonical Nucleosome-Remodeling BAF Complex in Foxp3 Expression and Regulatory T Cell Functio |
Zheng Y |
| 162 |
29892067 |
2018 |
NatMed |
CRISPR-Cas9 genome editing induces a p53-mediated DNA damage respons |
Taipale J |
| 163 |
30232004 |
2018 |
Cell Rep |
?Np63? Suppresses TGFB2 Expression and RHOA Activity to Drive Cell Proliferation in Squamous Cell Carcinoma |
Espinosa JM |
| 164 |
30323337 |
2018 |
Nat Commune |
Synthetic lethality between HER2 and transaldolase in intrinsically resistant HER2-positive breast cancer |
Wang XF |
| 165 |
30838976 |
2019 |
Elife |
Circular synthesized CRISPR/Cas gRNAs for functional interrogations in the coding and noncoding genom |
Kaulich M |
| 166 |
31903165 |
2019 |
Oncotarget |
CRISPR/Cas9 genome-wide screening identifies KEAP1 as a sorafenib, lenvatinib, and regorafenib sensitivity gene in hepatocellular carcinoma
|
Widmann C |
| 167 |
32528131 |
2020 |
Oncogene |
Ribosomal protein S11 influences glioma response to TOP2 poison |
Sonabend AM |
| 168 |
32968282 |
2020 |
Nature |
Functional genomic landscape of cancer-intrinsic evasion of killing by T cell |
Moffat J |
| 169 |
33147445 |
2020 |
Cell |
Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells
|
Sanjana NE |
| 170 |
33333024 |
2021 |
Cell |
Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses
|
Puschnik AS |
| 171 |
33382968 |
2021 |
Cell |
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Network |
Poirier JT |
| 172 |
33574281 |
2021 |
NatCommun |
A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entr |
Zhang R |
| 173 |
33686287 |
2021 |
NatGenet |
Genome-wide CRISPR screening identifies TMEM106B as a proviral host factor for SARS-CoV- |
Daelemans D |
| 174 |
33743211 |
2021 |
Cell |
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interaction |
Satpathy AT |
| 175 |
32649862 |
2020 |
Cell |
A Genetic Map of the Response to DNA Damage in Human Cell |
Durocher D |
| 176 |
33338421 |
2021 |
Cell |
TMEM41B Is a Pan-flavivirus Host Factor
|
Rice CM |
| 177 |
33357464 |
2021 |
Cell Host Microbe |
Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factor |
Rice CM |
| 178 |
31068700 |
2019 |
Nature |
Next-generation characterization of the Cancer Cell Line Encyclopedia |
William RS |